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Over time, this disrupts blood sugar regulation, suppresses immune surveillance, impairs collagen synthesis, and weakens bone, muscle, and connective tissue integrity

Data Collection Data were extracted from the included studies using a standardized data extraction form by 2 reviewers

This is the standard

Elevated lactate concentrations have been demonstrated to increase the NADH/NAD+ ratio, leading to the inhibition of key glycolytic enzymes such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoglycerate dehydrogenase, ultimately suppressing both glycolysis and mitochondrial respiration (85)