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Within the mitochondria CoA is an acceptor of carbons from the oxidation of carbohydrates (principally pyruvate derived via glycolysis), amino acids, fatty acids, and ketone bodies

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These effects were associated with the inhibition of NF-B nuclear translocation and reduced phosphorylation of B and mitogen-activated protein kinases, including p38, extracellular signal-regulated kinases 1 and 2 (Erk 1/2), and c-Jun N-terminal kinase (282)