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Vitamin A supplementation above 5,000 IU/day causes additive hypervitaminosis A toxicity [13]

According to FDA prescribing information, nausea occurs in 1544% of patients depending on the specific agent and dose, with vomiting, diarrhea, constipation, and abdominal pain also frequently reported

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Pucelik B, Barzowska A, Czarna A (2023) DYRK1A inhibitors leucettines and TGF- inhibitor additively stimulate insulin production in beta cells, organoids, and isolated mouse islets

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