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Phase 1 and Phase 2 clinical pharmacokinetic and weight-change studies

For normally distributed datasets, statistical significance between the two groups was assessed using two-tailed unpaired t-test with Welchs correction

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Additionally, our analysis could not discern the specific clinical indications for GLP-1RAs initiation during AKD due to the nature of database research, limiting our ability to fully contextualize prescribing decisions

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the clearest signal from trials and regulators points to gastrointestinal side effects like nausea and diarrhoea, which follow from GLP-1 action on the gut