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Bisphenols are widely used in the production of polycarbonates, epoxy resins, and thermal paper, and their presence is commonly recorded in both the environment and living organisms [429]
53 Notably, there is bidirectional communication between mtDNA and the nuclear genome: nuclear-encoded mitochondrial proteins regulate mtDNA replication and packaging, whereas mitochondrial metabolites affect nuclear gene expression through epigenetic modification, forming a mitochondrial-nuclear feedback loop
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