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If mitophagy fails, the accumulation of cardiolipin on damaged mitochondria can keep inflammasomes turned on (15)

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Mounjaro (tirzepatide) GLP-1 + GIP In SURMOUNT-1 (72 weeks), average weight loss at the highest dose was often quoted around: ~22.5% (highest dose) What that looks like: If you start at 100 kg , ~22.5% is about 2223 kg lost on average

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On a GLP-1, the shortfall becomes more severe

We did identify one instance of a clinic in Colorado advertising a GLP-1 compounded with BPC-157, a peptide about which the FDA lacks adequate safety information and has stated may trigger an immune response