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An important mechanism in GIO pathogenesis is associated with increased osteclastogenesis resulting from activation of macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B (NF-B) ligand (RANKL) [29]

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This mechanism distinguishes 5-Amino-1MQ from NAD+ precursors (NMN, NR), which provide substrate for NAD+ synthesis

International Journal of Women's Dermatology (2020)