The drug is being developed by Eli Lilly and Company, which has announced plans to progress retatrutide into Phase 3 clinical trials across multiple indications, including obesity, type 2 diabetes, and liver disease
NIH and Office of Dietary Supplements grants HL103866, HL126827, and DK106000, and the Leducq Foundation
YenY-WLeeY-LYuL-YLiC-EShuengP-WChiuH-Cet al
Wimberley T, Brikell I, Astrup A, Larsen JT, Petersen LV, Albiana C, et al
A notable proportion of participants in the higher-dose groups achieved HbA1c levels below 48 mmol/mol (6.5%) the diagnostic threshold for type 2 diabetes in the UK and some reached levels at or below 42 mmol/mol (6.0%), which falls within the range of non-diabetic hyperglycaemia as defined by UK and WHO criteria
Nevertheless, microbiome profiling could eventually help predict individual treatment responses more accurately among people with obesity and T2D