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However, when mitochondria are depolarized or damaged, PINK1 accumulates in large quantities in the OMM, translocating Parkin from the cytoplasm to the OMM by up-regulating its autophosphorylation and phosphorylating Parkin (ubiquitin, Ub) via its C-terminal kinase region [27]
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Possible mechanisms of skin aging mediated by GLP-1RA One possible mechanism leading to Ozempic face is the rapid loss of fat, which can alter the proportions of the face, resulting in facial aging
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