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The REMS was set to go into effect on 8 August, but the agency said it wants to allow more time to test the iPLEDGE REMS system updates, minimize technical issues for iPLEDGE REMS platform users, and ensure patients continue to have access to isotretinoin treatment

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Kim MH, Ha IJ, Kim E, Kim K (2020) Integrated targeted serum metabolomic profile and its association with gender, age, disease severity, and pattern identification in acne

Peer-reviewed literature doesnt focus on large-scale randomized controlled trials in humans and, because of this, human evidence is limited