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it is a complex, bidirectional biochemical signaling pathway that links the central nervous system (your brain) with the enteric nervous system (your gut)

Measurement of the apoB concentration should be, in addition to calculation of the non-HDL-C concentration, an alternative to LDL-C calculation when its accuracy is reduced [9, 50]

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(PubMed) Quinn JF, Raman R, Thomas RG, et al