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Excess adipose tissue is associated with chronic, low-grade inflammation, insulin resistance, abnormal cholesterol levels, high blood pressure and metabolic syndrome, all of which are associated with increased risk of heart disease and stroke

The bedtime timing aligns with the natural peak in growth hormone release that occurs during deep sleep

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As proof, ASCT2 ( SLC1A5 ) knockdown in osteosarcoma and cervical cancer cells can induce upregulation of SNAT1 ( SLC38A1 ) (Broer et al., 2016)