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Research uses MT-1 to study whether the anti-inflammatory and melanogenic arms of MC1R biology can be pharmacologically dissected through downstream pathway selective interventions examining whether PKA inhibition differentially affects the two outputs and contributing to understanding of how MC1R-cAMP signalling branches to produce distinct cellular outcomes simultaneously
This series is coordinated by Christopher W
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IL-1stimulated condition studies documented approximately 35% reductions in IL-8 production, with similar patterns observed for IL-6 and IL-1
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