Some argue that GLP-1RAs may exert neuroprotective effects indirectly via systemic mechanisms, while others suggest that more brain-penetrant incretins might be required for meaningful benefit
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This has a negative knock-on effect to all other areas of their lives including how they behave, think and socialize with others
The best non-diabetic body-composition anchor favors tirzepatide, about 75:25 fat-to-lean loss in its DXA data versus about 62:38 in semaglutides. This is cross-trial evidence, not a head-to-head maintenance-dose DXA result
Acne vulgaris is not listed as a recognised adverse effect in the MHRA-approved product information for semaglutide
This is likely due to greater weight loss seen in this trial, approximately 21% with 15 mg dosing, far exceeding the 14% weight loss observed in GLP-1 RA trials [14, 16, 19, 20, 23]