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However, our results are against the result of Xu et al (4)

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Further, in a comparison of levels of drug-metabolizing enzymes between transgenic or knockout mice and their parental strains using Western immunoblotting, increased expression of CYP2B and CYP3A isoforms was evident in XPA gene knockout mice with no differences from parental strains for rasH2, p53(+/-), and Tg.AC mice (Ariyoshi et al

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Together, these results suggest that IGF1 activates IGF1R through disrupting the autoinhibited apo state and stabilizing the active state of IGF1R