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A new study presented at the 2025 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS) examined how the timing of a patients last dose of Ozempic prior to total knee arthroplasty (TKA) or total hip arthroplasty (THA) influences anesthesia-related complications such as delayed emergence, aspiration, aspiration pneumonitis and conversion to intubation

So, there is a lot of reason to be excited about them

doi: 10.1371/journal.pone.0198024

9.1 Criteria suggesting failed pharmacology rather than failed biology Several characteristics consistently indicate that a peptide system may have been abandoned prematurely due to pharmacologic or methodological limitations rather than biological inadequacy

Early trials show an average of 24% weight loss over 48 weeks higher than semaglutide or tirzepatide