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In several reported pediatric cases, ingestion of large amounts of alpha-lipoic acid (for example, 2400 mg in a toddler) led to serious reactions such as seizures, loss of consciousness, or metabolic acidosis

Peer review Peer review information Nature Reviews Endocrinology thanks Michael Pollak and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

doi:10.1126/sciadv.aax6328

Furthermore, the REWIND trial demonstrated a 12% reduction in major adverse cardiovascular events (MACE) ( p = 0.026), including among patients without established cardiovascular disease, alongside renoprotective effects evidenced by reductions in albuminuria [56]

Outterson K, Powers JH, Daniel GW, McClellan MB

Its often enough if: Youre Healthy : Daily supplements or a diet rich in fruits and vegetables can maintain healthy levels