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Motif analysis using the MEME 42 revealed a notable enrichment of DAF-16 binding motif among the genes differentially expressed in glp-1(-) and fem-3(-) worms

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421,422 Remarkably, GLP-1R activation in certain nuclei (such as the VTA, NAc, and vHP) elicits reductions in food intake and body weight without concurrent nausea responses