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Semaglutide can help people lose an average of 18% of their body weight at the highest dose (Wegovy 7.2 mg), and tirzepatide has been associated with an average of 21% at the 15 mg dose of Zepbound

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Fourth, the absence of corroborating human genetic or observational evidence weakens the case for continued development, particularly when coupled with marginal preclinical effects

Consent to participate Informed written consent was obtained from all patients included in the study

Retatrutide has an estimated plasma half-life of approximately 6 days, supporting once-weekly subcutaneous dosing