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The impaired cross-talk between dysfunctional endothelial cells and fibroblasts further compromises angiogenesis, as endothelial cells provide critical paracrine signals (such as PDGF-BB) that recruit and activate fibroblasts, while fibroblasts produce VEGF and deposit the ECM scaffold necessary for endothelial tube formation

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Rigorously conducted Level 1 studies and cost/benefit analyses for these agents remain lacking at this time, though research is ongoing

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Apply a small amount on clean skin once or twice daily