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Dietary folates are absorbed by jejunal enterocytes primarily via the SLC46A1 encoded transporter which is a proton (H + )-coupled transporter more commonly referred to as the proton-coupled folate transporter, PCFT
The postmarketing experience section now includes reports of alopecia (hair loss) and dysesthesia (altered sense of touch)
Mechanism of Action Acetyl Group Protection : The attached acetyl group acts as a molecular shield, preventing digestive enzymes from breaking down glutathione prematurely in the stomach and intestines, which allows the intact molecule to reach target tissues like the liver, lungs, and brain
doi:10.3390/diseases13050127 10