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Using mice, the researchers investigated two areas in the brain stem, nucleus of the solitary tract (NST) and area postrema (AP), which are linked to feelings of satiety and vomiting responses, respectively

Indeed, there may be synergy between FGF-21 and GCG receptor agonism, due to their similar metabolic actions, particularly related to brown adipose tissue differentiation and activation [32], with FGF21 having additional actions in the liver, reducing hepatic lipogenesis and enhancing hepatic insulin sensitivity [66, 67]

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Defining endpoints upfront and reviewing at 3 to 6 months protects against this drift