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There are also instances where patients come in on a circumstantial basis if they: need an immune boost, want a hangover cure, are feeling under the weather, or are preparing for, or recovering from, a big athletic event like a marathon or other athletic competition

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The triggers of activating self-reactive clones are still to be determined, but may be common infections, molecular mimicry, or inflammation signals from gut microbiota (Westall, 2006)

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