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Epidemiological studies show a strong association between low vitamin D levels and increased risk of cognitive decline, while biological investigations highlight vitamin Ds neuroprotective effects through mechanisms like immunomodulation and neuroinflammation control

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A favorable effect was noticed on the level of IL-6 and IGF-1, but this effect did not reach a significant level

Women using oral contraceptives should be counseled about this interaction and may need to consider additional barrier methods of contraception, particularly during the first month of tirzepatide therapy or following dose increases

GLP-1RAs currently available on the market include semaglutide (sold as Ozempic and Rybelsus), liraglutide (Victoza), dulaglutide (Tulicity), exenatide ( Byetta and Bydureon ), and tirzepatide ( Mounjaro )