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Those are numbers that no single-agonist or dual-agonist peptide has achieved

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January 30, 2024

Diabetes 70 , 13471356 (2021)

86,87,88 Liraglutide was first approved by the FDA in 2010 under the brand name Victoza for the treatment of T2DM

In a randomized, single-blind, 24-week study, participants assigned to dual therapy of 2 mg weekly of the GLP-1 receptor agonist exenatide (Bydureon, AstraZeneca) and 10 mg daily of the SGLT2 inhibitor dapagliflozin (Farxiga, AstraZeneca) lost more weight than those taking either agent alone or those receiving dapagliflozin and metformin extended-release (Xigduo XL, AstraZeneca) or phentermine/topiramate extended-release (Qsymia, Vivus)