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in the genetic disorder Refsum disease, this system is impaired and phytanic acid accumulates in the plasma lipids

Trebaticky B, Muchova J, Ziaran S, Bujdak P, Breza J, Durackova Z

In a Phase 1 clinical trial, AMG133 demonstrated significant dose-dependent weight loss effects, achieving up to a 14.5% reduction in body weight compared to a 1.5% reduction for the placebo group on day 85

Interestingly, sex differences further highlight the role of GPER, with females exhibiting superior fatty acid metabolism, likely due to estrogen and its receptors [102, 103]

Recently, the Dietary Guidelines for Americans (2020-2025) recommended beverages, including coffee, as part of a healthy dietary pattern since they can contribute phytochemicals (7)

There is no first-in-human data