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BPA has a greater affinity for TR, particularly at low (0.001-0.1 M) concentrations 25,104 with low BPA reducing the recruitment/binding of cofactors necessary for transcription 105

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In addition, increased abundance of HisF (AFUA_2G06230) and cystathionine -lyase (AFUA_4G03950) shows an increased requirement for histidine and SAM respectively, necessary for the biosynthesis of EGT

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