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L.MllerL.GromannP.et al (2022)

Because they stay in the system for so long, its recommended to stop taking them at least two months before you plan to start trying to conceive

Studies have shown that impaired levels of insulin and an increase in insulin resistance lead to increased adipose lipolysis and FFA release into the circulation and their enhanced hepatic uptake, subsequently causing fat accumulation in the liver (Zhong et al., 2012

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Such missing heritability has been observed for many traits and diseases