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Glutamate-cysteine ligase catalytic and modulator subunits as well as GSH synthetase are the three NRF2 targets involved in the GSH synthesis (242)

Reported cases have occurred primarily in diabetic patients with significant renal insufficiency, including both intrinsic renal disease and renal hypoperfusion, often in the setting of multiple concomitant medical/surgical problems and multiple concomitant medications

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Filser, M

Diabetic complications | Treatment summaries | BNF NICE