1 For those taking Wegovy HD, 89% achieved 5% or greater body weight loss versus 38% taking placebo (from a baseline body weight of 248 lb.)
Signal was defined when the EBGM05 metric, a lower one-sided 95% confidence limit of the EBGM 2.0 [Reference Sakaeda, Tamon, Kadoyama and Okuno20] or the lower limits of the 95% confidence intervals (95% CIs) of ROR exceeded 1 in at least three reports [Reference Zhai, Ye, Hu, Xu, Guo and Lin21]
The retrospective real-world design is inherently subject to selection bias, missing data, and the absence of a randomized comparator, and the unequal duration of exposure at the two dose levels limits any formal assessment of dose effects independent of time-on-treatment
A provider who prescribes 1 mg weekly does not change that prescription when you switch between branded and compounded products
Hill JO, Kaler M, Spetalnick B, Reed G, Butler MG
While cyclodextrins have already improved treatment strategies for a variety of diseases, continued research will be essential to unlock their full capabilities
