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Semaglutide users in clinical trials lost 15 to 22 percent of body weight, while metformin typically results in 2 to 3 pounds of weight loss

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Patients should seek immediate care if they develop fever (temperature 100.4F or 38C), chills, flank pain, severe abdominal pain, persistent vomiting preventing oral intake, signs of dehydration (decreased urination, dark urine, dizziness, dry mouth), or altered mental status