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It is the key molecule mediating the specific uptake and accumulation of cisplatin in renal and cochlear tissues, as well as the core initiating factor of cisplatin-induced acute kidney injury and ototoxicity (Harrach and Ciarimboli 2015)

This multi-target metabolic reprogramming highlights the therapeutic potential of natural compounds in comprehensive cancer intervention

In real-world scenarios, the trade-off between effectiveness and side effects becomes clear

The question is whether inflammation is the whole story or only part of it

Constitutive MAPK phosphorylation and pharmacodynamic inhibitio of MEK/MAPK in relapsed/refractory primary acute myelogenous leukemia (AML) cells

Prog Cardiovasc Dis 2009;52:196203