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Observed Side Effects (From Clinical Trials) In the Lancet 2021 Phase 2 trial (n=706), at the highest 4.5 mg/week dose, 88% of participants reported at least one side effect and 63% reported a GI-specific event

The observed injuries in the lungs, heart, kidneys, and brain share a common mechanistic hallmark: glycocalyx shedding, increased vascular permeability, neutrophil adhesion, and oxidative stress [5, 17, 21, 104]

Understanding the intersection of autoimmune disease and modern weight loss therapy requires both clinical evidence and individualized medical oversight

Instead, it may possibly produce some fat-burning action via energy expenditure and fat oxidation

[1] Other causes include autoimmune conditions, certain infections, and inflammatory states that alter B12 metabolism or binding protein production

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