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Retatrutides triple-agonist design builds on these advances by addressing both energy intake and energy expenditure
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No controlled GLOW trial establishes a results timeline
Key findings from this phase 2 obesity trial included: Mean weight reduction of up to approximately 24.2% at the highest dose (12 mg) after 48 weeks Dose-dependent reductions in body weight across all active treatment arms Significant reductions in waist circumference, blood pressure, and lipid parameters Improvements in fasting glucose and insulin resistance markers A separate phase 2 trial in adults with type 2 diabetes (published in 2023) demonstrated meaningful HbA1c reductions alongside substantial weight loss, suggesting potential dual utility in both obesity and glycaemic management
When clinicians think of indications for GLP1-RA use in pediatrics, they primarily think of type 2 diabetes mellitus and obesity and goal for weight loss
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