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In contrast, NMDAR antagonist ketamine produces rapid antidepressant effects in treatment-resistant patients [16, 204]

[3] [5] Topical application also keeps the copper load overwhelmingly local: intact stratum corneum is a substantial barrier to a ~403 Da charged metal complex, which limits systemic copper exposure the same barrier property that limits topical efficacy is what limits topical copper risk

Diabetes Res Clin Pract 2014;104:9296

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