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Kraemer et al., 2020) and altering the expression of thousands of genes, many of which are involved in the regulation of skeletal muscle structure, fiber type (Dubois et al., 2013), and mRNA transcription (MacLean et al., 2008) (Figure 1)

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In addition to being delivered explicitly to the required tissues, they must reach the targeted cells, efficiently released into the cytoplasm, and exhibit in vivo biocompatibility