2.6.1.5 Effects of SL on liver fibrosis A team of Chinese researchers reported that SL inhibited HSC activation and hepatic apoptosis and prevented the formation of mallory-denk bodies in the NASH liver when SL was orally administered to the male C57BL/6 mice which were fed a MCD diet for 8 weeks, and the effect was related to alteration of lipid metabolism-related gene expression, activation of the Nrf2 pathway and inhibition of the NF-B signaling pathway in the NASH liver (Ou et al., 2018)
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[1] These effects are typically dose-dependent, most pronounced during dose escalation, and tend to diminish over time
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Duration of Therapy: 10 days Additional Notes: This protocol is designed to be administered up to twice per year
Exogenous administration of melatonin during the daytime reproduces this association, increasing fatigue and sleepiness and decreasing body temperature, especially if the subject is seated (posture dependent effect) (59)