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PLoS ONE 14:e0212856 Blackett JW, Sun Y, Purpura L, Margolis KG, Elkind MS, OByrne S, Wainberg M, Abrams JA, Wang HH, Chang L (2022) Decreased gut Microbiome Tryptophan metabolism and serotonergic signaling in patients with persistent mental health and Gastrointestinal symptoms after COVID-19

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Hence, cytokines may control adipocytes homeostasis by affecting local IGF-1 synthesis [160]

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Furthermore, this depletive process can be rescued after estrogen supplementation, increasing the number of spines (Luine and Frankfurt, 2013) and spine synapses in CA1 (Woolley and McEwen, 1992)