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IGF-1 LR3 directly activates IGF-1R on quiescent Pax7+ satellite cells within the basal lamina Akt-GSK-3--catenin and Akt-FoxO3a-Atrogin-1 axes drive satellite cell activation (MyoD upregulation), proliferation (EdU+ labelling +28-34% in 48h research), and differentiation (myogenin+ myotube formation index +22-28%)