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Iron chelator Deferoxamine mesylate (DFO) was purchased from Sigma (D9533)

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Research indicates that weight regain occurs in most individuals who discontinue the medication, underscoring that GLP-1 therapy addresses a chronic biological imbalance rather than providing a temporary fix

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Similarly, the US Yale-Penn sample found no significant associations between T2DM PRS and MDD in individuals of European ancestry, with only a nominal association between MDD PRS and diabetes in the same population [64]