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When the pancreas can no longer produce enough insulin to compensate for the reduced effectiveness of insulin, blood sugar levels continue to rise, eventually leading to diabetes

While it can be distracting, it is usually not cause for immediate concern

Caution is advised in patients with severe renal impairment mainly due to risk of volume depletion

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The cold fluid can also cause the surrounding tissues to contract slightly, increasing the pressure and discomfort as the volume of the dose is introduced

Taken together, these results may suggest that GLP-1 is an important mediator of the stress response in the brain