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Pyroglutamic acid (5-oxoproline), a glutamate cyclized derivative, also presented a higher abundance in OVX rat serum/urine samples that was significantly reversed by HPL therapy (Figure 3D, metabolite determination results are shown in Supplementary Tables S10)

10.3109/09513590.2010.507287 125 VishnubalajiR.YueS.AlfayezM.KassemM.LiuF

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