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Compared to NC group, we found that PI3K/-actin, p-AKT/AKT, and the ratio of p-mTOR/mTOR was down regulated, while semaglutide up-regulated the above proteins in a dose- response manner (Figure 8AD)

In AF mice, there was increased relative abundance of pathogenic Staphylococcus 36 , increased circulating PAGln levels, reduced nitrite, elevated LVEDP and reduced endothelial-dependent vasorelaxation (Fig