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2 Succinate supplementation or TMLHE inhibition decrease resistance to DNA damaging agents

GLP-1, a 30- or 31-amino-acid-long peptide hormone, is a gastrointestinal peptide secreted by the intestinal tract that potentiates insulin release and reduces glucagons concentration in physiological conditions (15, 16)

From a chemical perspective, the molecule is identified in the literature as retatrutide (LY3437943), a peptide with a triple receptor profile towards GIP, GLP-1 and the glucagon receptor (GCGR)

FIGURE 1 Measurement of insulin and GLP-1 Insulin and GLP-1 was quantified by ELISA kits

Endocrinology and Metabolism, 282(2)

Safety differs by peptide and dosage