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Based on these results, a phase IIb clinical trial (NCT01843075) demonstrated liraglutide improved cognitive function and MRI volume in patients with mild to moderate AD ( Lastly, inhibition of CypA-MMP-9 cascade, a pathway involved in BBB breakdown, in addition to repairing the BBB, also slowed down and reversed neurodegenerative changes in animal models (Table 1 presents BBB transporters/pathways implicated in AD and how they can be targeted

Valladares-Garrido, Vctor Juan Vera-Ponce Journal of Clinical Medicine.2026

Natural antioxidants like polyphenols, flavonoids, and carotenoids have low water solubility, leading to poor absorption in the gastrointestinal tract [32, 33]