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Xiao et al., 2022b)

while mitochondrial support may be genuinely life-changing for specific subsets of patients with measurable metabolic deficits, it is not a universal cure-all, emphasizing the urgent need for highly personalized medical approaches

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Evidence from a large cohort study involving over 104,000 treatment-nave individuals demonstrated a 17% reduction in the incidence of colorectal cancer among GLP-1RA users compared to those receiving metformin or DPP-4 inhibitors, suggesting a potential protective effect associated with GLP-1RA therapy [342]

The review is timely, as a number of primary reports shed exciting new insights into the role of the hypothalamus in regulating novel aspects of metabolic homeostasis including fatty liver disease. Abels next paper, Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression , homes in on this mechanism

Serious AEs occurred in 317% of patients, and up to 17% of patients permanently discontinued their assigned medication across background medication subgroups