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Despite the promising efficacy observed in Th- MYCN -derived 3D spheres, administration of the compounds resulted in gastrointestinal toxicity, including blocked intestine and stomach enlargement, necessitating early termination of the experiment

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Having everything ready ensures consistent protocol execution

PMID: 35013352 | doi:10.1038/s41598-021-03670-5 Yang M et al

Medvidovic-Grubisic M, Stambolija V, Kolenc D, Katancic J, Murselovic T, Plestina-Borjan I, et al

When taken orally, glutathione is largely broken down in the digestive system, reducing the amount that reaches the bloodstream and, consequently, the cells