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Thermal processes such as boiling or prolonged heating can result in up to 50% reduction in total phenolics, including luteolin, whereas controlled enzymatic or fermentative processing can enhance the aglycone content, thereby improving intestinal absorption and bioavailability ( 3.3 Pharmacokinetics and bioavailability A clear understanding of luteolins pharmacokinetic behavior is essential for translating its preclinical promise into therapeutic applications in reproductive disorders

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10.1002/ejhf.2346 73 MissailidisC.HllqvistJ.QureshiA

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The cell suspension was homogenized by passing through a 21-gauge needle and ultracentrifuged for 1 hour at 41,000 rpm at 4C