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Description

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Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors, distinguishing it from single agonists (Semaglutide) and dual agonists (Tirzepatide)

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Second, GLP-1R activation enhances neurovascular coupling function, improves cerebral blood flow and repairs BBB integrity, blocking the penetration of peripheral inflammatory factors into the center (Wong et al., 2024)

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