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Extended-release exenatide (Bydureon BCise) has an apparent terminal half-life of approximately 2 weeks due to its depot formulation, with drug concentrations potentially persisting for 8-10 weeks after discontinuation

In the Phase 2 obesity trial (NEJM, 2023), participants were assigned to different dose arms with varying escalation schedules

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EC 50 values at different concentrations of modulators were calculated and are plotted versus modulator concentrations for f , LSN3160440, and l , BETP